RECENT ADVANCES IN RENAL TRANSPLANT BY PERSONALIZING IMMUNOSUPPRESSIVE THERAPIES

Frontiers in Immunology

A paper about the Immunobiogram technology

José María Portolés, Carlos Jiménez, Darío Janeiro, María O. López-Oliva, Álvaro Ortega- Carrión, Daniel Blanquez, Luis Arribas, Carlos Gómez, Teresa Diez, Julio Pascual e Isabel Portero.

“The Immunobiogram, a Novel In Vitro Assay to Evaluate Treatment Resistance in Patients Receiving Immunosuppressive Therapy”

Key findings in the paper are:

  • Not all patients respond equally to a given immunosuppressant drug. This is due to individual differences in pharmacokinetic and pharmacodynamic responses to drugs
  • The IMBG test allows quantification of each patient’s sensitivity to their prescribed immunosuppressant medication. Furthermore, we observed an association between patient treatment results and the immunological risk of rejection of the corresponding patient
  • Patients with a greater risk of rejection showed reduced sensitivity to their prescribed immunosuppressant, while those with the lowest risk of rejection showed greater sensitivity to their prescribed medication.
  • The IMBG assay thus provides pharmacodynamic information linked to the final efficacy of the patient’s prescribed immunosuppressant(s), which influences their risk of rejection
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Click here to download IMBG publication

28th International Congress of the Transplantation Society  

Virtual TTS 2020 (13-16 September)

ePoster

Julio Pascual, Carlos Jiménez, Magdalena Krajewska, Daniel Seron, Camille Kotton, Jose María Portolés, Oliver Witzke, Soren Sorensen, Amado Andrés, Teresa Diez , Álvaro Ortega, Isabel Portero.

“Analysis of Immunobiogram pharmacodynamic dose-response curves to immunosuppressants in kidney transplant recipients: further results from Transbio Study Abstract #604.”

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Sociedad Española de Trasplantes 2021

SET 2021 6º Congreso 12-14 Febrero (virtual)

ePoster

Julio Pascual1, Carlos Jiménez2, Daniel Seron3, Jose María Portolés4, Amado Andrés5, Teresa Díez6, Alvaro Ortega6 e Isabel Portero6 en representación del TRANSBIO Study group.

” Inmunobiograma, un nuevo inmunoensayo de diagnóstico in-vitro para facilitar el ajuste individualizado del tratamiento inmunosupresor en trasplante renal:  Estudio TRANSBIO.”

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American Transplantation Congress  

ATC  2020 30 May -3th June 2020, Philadelphia

ePoster

Rubio C, Jiménez C, Crespo M, Portolés J, Rubio D, Diez T, Portero I.

“Evaluation of the Economic Impact of a New IVD Immunoassay (Immunobiogram) for Immunosuppressive Treatment Adjustment in Kidney Transplant Recipients in Spain [abstract]. Am J Transplant. 2020; 20 (suppl 3).”

Oral abstract presentation

Pascual J, Jiménez C, Krajewska M, Kotton C, Seron D, Portolés J, Witzke O, Sorensen SS, Andrés A, Díez T, Ortega A, Portero I.

“TRANSBIO Study: Clinical Evaluation of Immunobiogram, a Novel In Vitro Diagnostic Immunoassay to Guide Adjustment of Immunosuppressive Therapy in Kidney Transplantation [abstract]. Am J Transplant. 2020; 20 (suppl 3).”

 Congreso Sociedad Madrileña de Trasplantes

CSMT 2019 (20 al 22 de noviembre, Madrid)

Abstract /Poster

Jimenez C, Lopez M, Vaca MA, González E, Santana MJ, Portoles JM, Pascual J.

“Ajuste del tratamiento inmunosupresor en dos receptores de trasplante renal. Utilidad del perfil de sensibilidad / resistencia a inmunosupresores del Immunobiograma.”

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International Society for Pharmacoeconomics and

Outcomes Research

ISPOR Europa 2019 (2-6 November 2019, Copenhagen)

Poster

Díez T, Portero I, Jimenez C, Crespo M, Portoles JM, Rubio-Terrés C, Rubio-Rodríguez D.

“Economic evaluation of an in vitro diagnostic assay (Immunobiogram) in the selection and dose titration of immunosuppressive therapy (IS) in kidney transplant patients in Spain“.

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ESOT  2019 (September, Copenhagen)

European Society of Organ Transplantation 

Poster:

Julio Pascual, Carlos Jiménez, Magdalena Krajewska, Camile Kotton, Daniel Seron, Jose María Portolés, Oliver Witzke, Soren S Sorensen, Amado Andrés, Teresa Díez, Álvaro Ortega, Isabel Portero on behalf of TRANSBIO Study group.

“Analytical robustness and clinical consistency evaluation of a new in vitro diagnostic BIOtechnological immunoassay to help decision-making in adjustment of immunosuppressant therapy for kidney TRANSplantation”.

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American Transplantation Congress  

ATC  2019 (1-5 June 2019, Boston)

Poster:

Carlos Jiménez, Jose María Portoles, Daniel Blánquez, Luis Arribas, Álvaro Ortega, Teresa Díez, Isabel Portero on behalf of TRANSBIO STUDY GROUP.

“Immunobiogram, A New IVD Immunoassay To Test The Sensitivity Profile Of Kidney Transplant Recipients To Immunosuppressive Drugs: Further Results From BH-pilot Study”.

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Basic Science Transplantation Congress 

BST 2018 (11-13 October 2018, Rotterdam)

Poster

Di Scala Marianna, Portolés José Maria, Jiménez Carlos, Janeiro Dario, González Elena, Sánchez Sobrino Beatriz, López Oliva María, Richter Jose, Ortega Álvaro, Pascual Julio, Portero Isabel.

“Immunobiogram: a new immunological tool to personalize immunosuppressive therapy in kidney transplant recipients”

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5th European Congress of Immunology 2018

ECI 2018 (2-5th September, Amsterdam)

Workshop (Oral presentation): Di Scala, J. Portolés, C. Jiménez, D. Janeiro , E. González , B. Sánchez Sobrino , M. López Oliva, J. Richter , A. Ortega, J. Pascual , I. Portero.

“ IMMUNOBIOGRAM a new immunological tool to personalize immunosuppressive therapy in kidney transplant recipients.”

Poster: Á. Ortega, M. Di Scala, T. Yebra, T. Diez, J. Richter, I. Portero.

“BIOHOPE Scientific SL, Madrid, Spain “Immunobiogram as a diagnostic assay for detection of resistance to immunomodulatory treatment in patients with chronic inflammatory diseases”.

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27th International Congress of the Transplantation Society

TTS 2018 (1-5th  July, Madrid)

Lunch & Learn session:

“IMMUNOBIOGRAM: A Novel Precision Medicine Tool to Help Guidance of Immunosuppression in Renal Transplantation. Results of “BH-Pilot 2015” Proof-of-Concept Clinical Study” by Prof. Julio Pascual from Hospital del Mar, Barcelona.

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